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Fig. 8 | Cancer & Metabolism

Fig. 8

From: RHOF promotes Snail1 lactylation by enhancing PKM2-mediated glycolysis to induce pancreatic cancer cell endothelial–mesenchymal transition

Fig. 8

Silencing of RHOF inhibits PC tumor growth and EMT in xenograft mouse models. A Image of xenograft tumor. B The volume of xenograft tumor. C The weight of xenograft tumor. D Representative images of TUNEL assays and IHC for detecting Ki67 and CD31 positive cells. E Ki67-positive cells in tumor tissues. F TUNEL-positive cells in tumor tissues. G Immunofluorescence co-localization detection of Kla and Snail1. H Western blot was utilized to estimate the protein expression of c-Myc, PKM2, and Snail1. I The protein expression of E-cadherin, Vimentin, and N-cadherin was estimated using Western blot. n = 5. Data were analyzed using paired t-test

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Cancer & Metabolism

ISSN: 2049-3002