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Fig. 1 | Cancer & Metabolism

Fig. 1

From: Unveiling the powerhouse: ASCL1-driven small cell lung cancer is characterized by higher numbers of mitochondria and enhanced oxidative phosphorylation

Fig. 1

ASCL1 expression is associated with an oxidative phenotype in SCLC according to proteomic data. (A) ToppCluster analysis of significantly overexpressed proteins in the SCLC-A subtype (DMS153, DMS53, SHP77, H146, H1688, H1882, H209, H378) based on the comparison to non-SCLC-A cell lines (GLC4, H1694, H2171, H446, H524, H82, N417, COR-L311, H1048, H211, H526, CRL-2066, CRL-2177, H1341, H196, H372, H841, HLHE). The FDR cut-offs for KEGG (illustrated as a circle) and GOPB (shown as squares) pathways were 0.05 and 0.01, respectively. Hexagons imply the proteins related to the significant pathways. (B) Significantly overexpressed proteins COX4I1, COX5B and NDUFA5 in SCLC-A (blue) in SCLC-A cell lines compared to SCLC-N/P/Y (orange). Statistical significance was evaluated using the Kruskal-Wallis test. Data are represented as mean ± SEM. (C) Gene set enrichment analysis (GSEA) showing enriched oxidative phosphorylation in SCLC-A. (D) Differentially expressed pathways in SCLC-A resulting from GSEA. The y-axis indicates the normalized enrichment score (NES). * p ≤ 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001

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Cancer & Metabolism

ISSN: 2049-3002