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Fig. 5 | Cancer & Metabolism

Fig. 5

From: Similar deficiencies, different outcomes: succinate dehydrogenase loss in adrenal medulla vs. fibroblast cell culture models of paraganglioma

Fig. 5

Distinct transcriptomic changes upon SDH loss in imCCs (A) or iMEFs (B). Data are displayed as volcano plots where genes shown in back are differentially expressed [p-value < 0.05, Log2(FC) > 1.5]. (C) Scatter plot showing relatively poor correlation between Log2(FC) values for RNA transcripts changed upon SDH loss in imCCs (x-axis) and iMEFs (y-axis). (D) For comparison, relatively strong correlation is observed for expressed transcripts between WT imCCs (x-axis) and SDH-loss imCCs (y-axis). E and F. Volcano plots show differential expression of RNAs encoding components of Complex I upon SDH loss in imCCs (E) or in iMEFs (F). Labelled genes are differentially expressed [p-value < 0.05, Log2(FC) > 1.5]

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Cancer & Metabolism

ISSN: 2049-3002