Fig. 2

Differentially detected metabolites among patient groups. A Principal component analysis plot showing a relatively discrete HC cluster and a widely distributed LM cluster. B Supervised clustering (LM vs. HC) heatmap of 117 samples with CSF metabolomes was generated using 201 metabolites measured > 90% of samples. Notes: BM, brain metastasis; BT, brain tumor; HC, healthy control; ID, inflammatory disease; LM, leptomeningeal metastasis; AA, aminoacids; BA, biogenic amines; AC, acylcarnitines; CE, cholesteryl esters; DG, diglycerides; TG, triglycerides; PC, phosphatidylcholines; Cer, ceramides; SM, sphingomyelins; H1, hexoses