Fig. 4
From: Pancreatic cancer tumor organoids exhibit subtype-specific differences in metabolic profiles
Differential gene expression analysis between PDOs from basal-like and classical tumors. (a) Volcano plot of differentially expressed genes between PDOs from basal-like and classical tumors. Expression in basal-like PDOs is shown in reference to classical PDOs. (b) Bar plots showing gene set enrichment analysis performed on up (top; red) and down (bottom; blue) regulated genes in basal-like PDOs compared to classical PDOs. Genes enriched in basal-like PDOs are belong to pathways that associate with aggressive tumors (c) Kaplan-Meier survival curves depicting association of median overall survival with gene expression quantiles in a cohort of PDAC metastatic biopsies (PanGen, n = 69)