Fig. 3
From: Pancreatic cancer tumor organoids exhibit subtype-specific differences in metabolic profiles
UK-5099 leads to a subtype-specific decrease in 13C labelling of glycolysis and TCA cycle metabolites. (a) Illustration of metabolites generated during glycolysis and TCA cycle with carbon backbone lengths. Black dots represent 12C and red dots 13C. (b) Bar plots showing fractions of labelled (M + 2/M + 3) carbon pool for glycolysis and TCA cycle metabolites along with select amino acids; following DMSO and UK-5099 (5𝜇M) treatment in PCBC-015 (basal-like) and PCBC-006 (classical). *p < 0.05, **p < 0.01, ***p < 0.001 (students t-test)