Fig. 7
From: Hypoxia-induced NOS1 as a therapeutic target in hypercholesterolemia-related colorectal cancer
Schematic diagram delineating hypercholesterolemia induces the oxidant stress-dependent induction of hypoxia signaling to transcriptionally up-regulate NOS1 expression in CRC cells, and the selective NOS1 inhibitor Nω-Propyl-L-arginine represents an effective therapeutic strategy for hypercholesterolemia-related CRC