Fig. 6
From: Hypoxia-induced NOS1 as a therapeutic target in hypercholesterolemia-related colorectal cancer
Pharmacologic blockade of NOS1 is a promising therapeutic strategy for hypercholesterolemia-related CRC. A Cell growth and B colony formation of oxLDL-treated HCT116 cells incubated with or without Nω-Propyl-L-arginine. C Study design of the used HCD-induced hypercholesterolemia murine model. D Waterfall plot of the response of HCT116 xenografts at 4 weeks after the starting dose of Nω-Propyl-L-arginine administration. E Tumor weight of vehicle- or Nω-Propyl-L-arginine-treated mice at 4 weeks after the starting dose of drug administration. Two-tailed Student’s t-test (A, B, D, and E). Error bars represent ± SD. **p < 0.01, ***p < 0.001. Data represent mean ± SD of at least three independent experiments