Fig. 1

Hypercholesterolemia increases the incidence and histopathologic severity of colorectal neoplasia. A Study design of the used hypercholesterolemic ApoE^−/− murine model. N = 6. B Average tumor number per mouse from WT and ApoE^−/− mice. C Histopathologic stages of the tumors from WT and ApoE^−/− mice. D Representative images of H&E and Ki-67 immunohistochemical staining for CRC samples from WT and ApoE^−/− mice. Scale bars, 200 μm. Two-tailed Student’s t-test (B and C). Error bars represent ± SD. **p < 0.01, ***p < 0.001. Data represent mean ± SD of at least three independent experiments