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Fig. 5 | Cancer & Metabolism

Fig. 5

From: BCAA metabolism in pancreatic cancer affects lipid balance by regulating fatty acid import into mitochondria

Fig. 5

BCAA-derived carnitines respond as regulators of LC-CAR oxidation. a Log2 fold change in BCAA-CARs with -BCAA treatment quantified by LC-MS method. Paired t-test. N > 3, n ≥ 9. Criteria of significance: ***p < 0.001, ****p < 0.0001. b Rescue effect of BCAA-CARs under BCAA-depleted conditions with BCKA, free carnitine, and other compounds relevant to mitochondrial metabolism. c Confocal microscopy demonstrating the rescue effect of mitochondrial FA import with BCAA (o/n), BCKA (48 h), and free L-carnitine (1 mM, o/n) treatment

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Cancer & Metabolism

ISSN: 2049-3002