Fig. 1
From: Targeting MYC-enhanced glycolysis for the treatment of small cell lung cancer
MYC directly upregulates glycolysis expression. A–C Bimodal MYC gene stratification of SCLC samples in the George et al., Gay et al., and Sato et al. datasets [11, 37, 38]. D Venn diagram showing the 266 upregulated gene commonalities among the three datasets. E Of the 266 upregulated genes, 36.9% can be linked to a metabolic process through Panther Gene Ontology Biological Pathway Analysis. F Similarly, several of the top GO terms generated by David Functional Enrichment Analysis are involved in central carbon and glucose metabolism. G and H Glycolysis genes HK2, PFKFB3, and LDHA exhibit increased expression in the MYCHigh subset of patient tumors [11] and cell lines [37], respectively. I HK2, PFKFB3, and LDHA protein expression by RPPA is also increased in MYCHigh cell lines. J ChIP-seq analysis of MYC (red) and H3K27Ac (blue) genomic binding at indicated gene loci from N = 4 RPM tumor samples. Arrows indicate directionality of the gene