Fig. 1

Quantitative proteomic analysis of TNF-α regulated mitochondrial proteins in breast cancer cells. a Immunoblot analysis of isolated mitochondria. b Molecular functions of DEPs by IPA tool. The x-axis indicates the number of proteins, red bar as upregulated, and orange bar as downregulated proteins. c Volcano plots of DEPs displayed in the p-value (−log10) versus signal-to-noise ratio (STN). The p-value and STN were determined by power law global error model (PLGEM) statistical analysis for label-free quantification