Fig. 4

Connectivity analysis between metabolism and tumor growth of lung tumor and colon tumor-bearing mice. a, b The network of connections of A549 (a) and HCT116 (b) xenografts tumor in the control condition. c, d The network of connections of A549 (c) and HCT116 (d) xenografts tumor under combined treatment condition. All networks are specific for each tissue and obtained by keeping only the connections not shared between the two tissues. In each network, nodes represent metabolites. Nodes color corresponds to the different metabolic classes and tumor size, whereas the color of the edges indicates positive (light blue) or negative (light red) correlation. A greater size highlights nodes of interest