Fig. 4

Cellular energy homeostasis is disrupted with metabolic inhibitors. AMPK-mTORC1 signalling in a Hs578T cells treated with 0.5 and 4 mM 2DOG for 2 days, b ESH-172 cells treated with 2 and 4 nM oligomycin for 2 days and c ESH-72 cells treated with 1 and 4 mM metformin for 2 days. All data are mean ± SEM, n = 3 biological replicates/group. *p < 0.05 vs. vehicle