Mathematical models of cancer metabolism

Table 2 Kinetic models. Selected kinetic models of metabolic pathways, focusing on reaction kinetics and parameters for mammalian cells

Pathway	Tissue	Major conclusion	Reference
Glycolysis	Cancer cells	Glycolysis has different control steps depending on cell line	[88]
Glycolysis	Cancer cells	GAPDH is the rate limiting step of glycolysis	[89]
Pentose phosphate pathway	Hepatocytes	G6P dehydrogenase controls the oxidative rate and transketolase the non-oxidative rate	[90]
One-carbon metabolism	Hepatocytes	Mitochondrial formate is the major source of cytosolic one-carbon units in proliferating hepatocytes	[91]
H₂O₂ elimination	Endothelial cells	GSSG reductase controls the NAPDH dependent H₂O₂ elimination	[92]
Mitochondria	Hepatocytes	The rate of superoxide generation is a function of the proton electrochemical potential	[93]
Central metabolism	Cancer cells	Repression of transaldolase and succinyl-CoA ligase and the synergistic combination of transaldolase and serine hydromethyltransferase significantly reduce growth rate	[94]

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